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In Crustacea, the neuroendocrine X-organ andsinus gland complex in the eyestalk has long beenknown to play an important role in the regulation ofmolting and female reproduction (see reviews1–4).The roles of the X-organ-sinus gland complexwere originally demonstrated by eyestalk ablationexperiments in the early works of Zeleny,5Smith6 and Panouse.7 As eyestalk ablation causedthe stimulation of molting and female reproduction,the existence of inhibiting factors in theeyestalk was postulated. In recent studies, theseinhibiting factors were purified as neuropeptide
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