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Sterol Regulator Element-Binding Protein 1c (SREBP) Targeted overexpression of the insulin-regulated transcription factor sterol regulator element-binding protein 1c (SREBP1) in adipose tissue has also been shown to results in the development of NAFLD in mice [29,30]. In this model the development of fatty liver was associated with alterations in thedifferentiation of white adipose tissue and hyperinsulinemia but also mild hepatic inflammation and fibrosis; however, body weight did not differ from wild-types and development of adipose tissue was markedly altered [29].
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