Summary: Aminoacyl-tRNA synthetases catalyze the aminoacylation of
tRNA by their cognate amino acid. Because of their central role in
linking amino acids with nucleotide triplets contained in tRNAs,
aminoacyl-tRNA synthetases are thought to be among the first
proteins that appeared in evolution. Two forms of tryptophanyl-tRNA
synthetase exist, a cytoplasmic form, named WARS, and a
mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase
(WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan
and is induced by interferon. Tryptophanyl-tRNA synthetase belongs
to the class I tRNA synthetase family. Four transcript variants
encoding two different isoforms have been found for this gene.
[provided by RefSeq, Jul 2008].
Transcript Variant: This variant (3) lacks an alternate exon
compared to variant 1. The resulting isoform (b) uses a downstream
start codon but has the same C-terminus compared to isoform a.
Variants 3 and 4 both encode isoform b.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.