Our findings highlight the need for work-related interventions designed to prevent sharps injuries and other blood and body fluid exposures among home health care nurses and aides. As these interventions are developed, we believe it is important to consider that, despite occupational safety and health hazards, the majority of nurses and aides are satisfied with their work. As we develop public health interventions aimed at improving safety, we need to preserve and enhance those aspects of the job that make dignified, meaningful care possible.