Proteases constitute one of the most important groups of industrial enzymes, accounting for
about 60% of the total enzyme market. A protease is an enzyme that conducts proteolysis,
that is, begins protein catabolism by hydrolysis of the peptide bonds that link amino acids
together in the polypeptide chain forming the protein[1,2]. For several physiological
processes the action of the proteolytic enzyme is essential , e.g. in digestion of food proteins,
protein turnover, cell division, blood clotting cascade, signal transduction, processing of
polypeptide hormones, apoptosis and also in the life cycle of disease-causing organisms
including the replication of retrovirus[4]. With special reference to their key role in life-cycle