Considering that cellular mechanism

Considering that cellular mechanisms of regeneration
can dramatically differ between species and cellular
lineages, it is difficult to predict to what extent molecular
principles regulating regeneration are conserved. Yet, regeneration
of any complex structure requires molecular
solutions to similar problems. These include: (i) which
molecular cues sense and initiate the regenerative program
in response to injury; (ii) how regenerative growth is
controlled (that is, how cell proliferation, differentiation,
and pattern formation are coordinated); and (iii) by which
mechanisms the regenerative program is terminated when
the structure has reached its pre-injury size.
Although some progress has been made in defining early
wound-sensing signals (for example, from the immune
system) that are required to initiate vertebrate regeneration
[10–13], the issue of regeneration termination at the
right time and size (i.e., positional memory) remains poorly
understood [14]. In this review we focus on the molecular
control of regenerative fin growth, where the most progress
has been made. Other fascinating facets of fin regeneration
have been recently discussed in excellent reviews and are
not covered here [15,16].

Results (Indonesian) 1:

Mengingat bahwa mekanisme selular regenerasidapat secara dramatis berbeda antara spesies dan selulerketurunan, sangat sulit untuk memprediksi sampai tingkat molekulerprinsip-prinsip yang mengatur regenerasi dilestarikan. Namun, regenerasisetiap struktur kompleks membutuhkan molekulersolusi untuk masalah yang sama. Ini termasuk: (i) yangmolekul isyarat masuk akal dan memulai program regeneratifdalam menanggapi cedera; (ii) bagaimana regeneratif pertumbuhandikendalikan (yaitu bagaimana sel proliferasi, diferensiasi,dan pola pembentukan terkoordinasi); dan (iii) yangmekanisme program regeneratif diakhiri ketikastruktur ini telah mencapai ukuran pra-cedera.Meskipun beberapa kemajuan telah dibuat dalam menentukan awalluka-sensing sinyal (misalnya, dari kekebalansistem) diperlukan untuk memulai vertebrata regenerasi[10-13], masalah regenerasi penghentian diwaktu yang tepat dan ukuran (yaitu, posisi memori) tetap burukmengerti [14]. Dalam tinjauan ini kami fokus pada molekulpengendalian pertumbuhan sirip regeneratif, mana yang paling kemajuantelah dibuat. Aspek lainnya menarik sirip regenerasiBaru-baru ini telah dibahas dalam review yang sangat baik dantidak tercakup di sini [15,16].