An examination of the current state

An examination of the current state of hepatotoxic biomarkers indicates that serum F protein, arginase I, and glutathione-S-transferase alpha (GST) levels, all measured by ELISA, may show utility,however, antibody availability and high cost per run may present limitations to widespread applicability in preclinical safety studies.
In contrast, the enzymatic markers sorbitol dehydrogenase, glutamate dehydrogenase, paraxonase, malate dehydrogenase, and purine nucleoside phosphorylase are all readily measured by photometric methods and use reagents that work across preclinical species
and humans and are commercially available. The published literature suggests that these markers, once examined collectively in a large qualification study, could provide additional information relative to serum ALT and aspartate aminotransferase (AST) values.
Since these biomarkers are found in the serum/plasma of treated humans and rats, they have potential to be utilized as bridging
markers to monitor acute drug-induced liver injury in early clinical trials.
© 2007 Elsevier Ireland Ltd. All rights reserved

Results (Indonesian) 2:

Pemeriksaan keadaan saat biomarker hepatotoksik menunjukkan bahwa protein serum F, arginase saya, dan glutathione-S-transferase alpha (GST) tingkat, semua diukur dengan ELISA, dapat menunjukkan utilitas, bagaimanapun, ketersediaan antibodi dan biaya tinggi per run dapat hadir keterbatasan penerapan luas dalam studi keamanan praklinis.
Sebaliknya, spidol enzimatik dehidrogenase sorbitol, glutamat dehidrogenase, paraxonase, dehidrogenase malat, dan purin nukleosida fosforilase semua mudah diukur dengan metode fotometrik dan penggunaan reagen yang bekerja di seluruh spesies praklinis
dan manusia dan komersial tersedia. Literatur yang diterbitkan menunjukkan bahwa tanda tersebut, setelah diperiksa secara kolektif dalam studi kualifikasi besar, bisa memberikan informasi tambahan dibandingkan dengan serum (AST) nilai-nilai ALT dan aspartat aminotransferase.
Sejak biomarker ini ditemukan dalam serum / plasma manusia diperlakukan dan tikus, mereka memiliki potensi untuk dimanfaatkan sebagai bridging
penanda untuk memantau kerusakan hati akibat obat akut dalam uji klinis awal.
© 2007 Elsevier Ireland Ltd All rights reserved