Domain Architectures Conserved Doma

Domain Architectures
Conserved Domain Architecture Retrieval Tool (CDART) performs similarity searches of the Entrez Protein database based on domain architecture, defined as the sequential order of conserved domains in protein queries. CDART finds protein similarities across significant evolutionary distances using sensitive domain profiles rather than direct sequence similarity. Proteins similar to the query are grouped and scored by architecture. You can search CDART directly with a query protein sequence, or, if a sequence of interest is already in the Entrez Protein database, simply retrieve the record, open its "Links" menu, and select "Domain Relatives" to see the precalculated CDART results (illustrated example). Relying on domain profiles allows CDART to be fast and, because it relies on annotated functional domains, informative.
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Domain Arsitektur
Lindung domain Arsitektur Retrieval Tool (CDART) melakukan pencarian kesamaan dari Entrez Database Protein berdasarkan arsitektur domain, didefinisikan sebagai berurutan domain dilestarikan dalam permintaan protein. CDART menemukan kesamaan protein melintasi jarak evolusi yang signifikan menggunakan profil domain sensitif daripada langsung kesamaan urutan. Protein mirip dengan query dikelompokkan dan dicetak oleh arsitektur. Anda dapat mencari CDART langsung dengan urutan protein query, atau, jika urutan kepentingan sudah dalam Entrez Database Protein, hanya mengambil catatan, buka menu "Link", dan pilih "Domain Saudara" untuk melihat hasil CDART precalculated (diilustrasikan misalnya). Mengandalkan profil domain memungkinkan CDART menjadi cepat dan, karena itu bergantung pada domain fungsional dijelaskan, informatif.
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