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Conventional methods measure only a-priori selected EPs.In recent years generic chemical screening approachesbased on chromatography with full scan mass spectrometry have become increasingly popular to complement orreplace existing targeted methods (Hernández et al.,2012). In contrast to conventional targeted methods , the sampleis analyzed in a comprehensive way and in essence one can decide afterwards which EPs of interest to retrieve fromthe raw data.This is an effective way of screening samples for very high numbers of EPs and an economical way topick up unexpected EPs for which application of quantitative targeted methods with all associated analytical qualitycontrol is not justifiable. Other important advantages are the ability of retrospective detection of additional EPswithout the need for re-sampling/re-analys is of the sample,and detection and identification of unknowns. A hurdlestill to be taken to fully benefit from the potential of this technology in routine practice is the availability of adequatedata processing software and associated databases.
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