These changes seem toowe to the alt

These changes seem to
owe to the alterations in the treatments predominantly used for
TEN between these 2 time periods. More cases were treated with
the combination of corticosteroid therapy and PE at the early stage
of each disease after 2007, because plasmapheresis as a treatment
for SJS and TEN became eligible for coverage by health insurance in
April 2006 in Japan. In addition, IVIG therapy at a dose of more than
2 g/kg was started in these latter years. In these patients, each
treatment was started immediately one after another, when the
initial treatment was thought not to be effective enough. From
these facts, it is likely that treatments based on steroid therapy in
combination with plasmapheresis and possibly IVIG are effective in
SJS and TEN. The major factors influencing the efficacy of combination
therapy seem to be the dose of steroids and timing of start of
each treatment.
In conclusion, improvement of mortality of SJS/TEN was
observed in 2007e2013, compared with 2000e2006. Treatment
with steroids in combination with plasmapheresis and/or IVIG
more than 2 g/kg seems to have contributed to this improvement.
To inform the development of guidance as to the optimum treatment
regimen, RCT studies are required. However, it is difficult to
perform RCT for these diseases because of ethical problems.

Results (Indonesian) 1:

Perubahan ini tampaknyaberutang kepada perubahan dalam perawatan yang sebagian besar digunakan untukSEPULUH antara 2 periode waktu. Kasus lain diperlakukan dengankombinasi terapi kortikosteroid dan PE pada tahap awalsetiap penyakit setelah 2007, karena Plasmaperesis sebagai pengobatanuntuk SJS dan sepuluh menjadi layak untuk cakupan melalui asuransi kesehatan diApril 2006 di Jepang. Selain itu, IVIG terapi dengan dosis lebih dari2 g/kg dimulai pada tahun-tahun terakhir ini. Pada pasien ini, setiappengobatan dimulai segera setelah satu, ketikapengobatan awal dianggap tidak cukup efektif. Darifakta ini, sangat mungkin bahwa perawatan berdasarkan terapi steroidkombinasi dengan Plasmaperesis dan mungkin IVIG efektif dalamSJS dan sepuluh. Faktor-faktor utama yang mempengaruhi kemanjuran kombinasiTerapi tampaknya dosis steroid dan waktu awalSetiap perlakuan.Kesimpulannya, peningkatan mortalitas SJS sepuluh adalahdiamati di 2007e2013, dibandingkan dengan 2000e2006. Pengobatandengan steroid dalam kombinasi dengan Plasmaperesis dan/atau IVIGlebih dari 2 g/kg tampaknya telah berkontribusi terhadap peningkatan ini.Untuk menginformasikan perkembangan bimbingan pengobatan optimalrejimen, RCT studi diperlukan. Namun, sangat sulit untukmelakukan RCT untuk penyakit ini karena masalah etis.