Ebola in Animals: Non-human primate

Ebola in Animals: Non-human primates are in general highly susceptible to Filovirus infections. Large outbreaks of lethal Ebola virus infection have been reported in wild populations of gorillas (Gorilla gorilla) and chimpanzees (genus pan ). In rhesus monkeys ( Macaca mulatta ), cynomolgus monkeys (Macaca fascicularis ), African green monkeys ( Cercopithecus aethiops ) and baboons (Papio species) inoculated with Marburg virus or Zaire Ebola virus the incubation period of 4-6 days is followed by an abrupt onset of clinical disease marked by petechiae, ecchymosis, hemorrhagic pharyngitis, hematemesis, melena and prostration. Infection nearly always ends in death. The pathogenesis of filovirus infections is apparently similar in those non-human primates and humans. Mice and guinea pigs are not highly susceptible to field isolates of filoviruses but rodent adapted strains of the viruses do induce uniformly lethal disease and have been utilized for testing vaccines and therapeutic agents [15]. When inoculated experimentally in various monkey species, the Ebola virus causes severe disease characterized at first by fever and depression followed by diarrhea, petechiae, languor, shock and finally death [28].In the Cynomolgus macaques imported in to Italy and the United States from the Philippines, the infection caused by the Reston strain of the virus produced disease and a high case fatality rate. Antibodies have also been found in other old world primates [21]. The Sudan and Reston subtypes of Ebola virus are least pathogenic for primates and guinea pigs, killing only a fraction of animals inoculated with un-passaged virus. Serial passage increases the virulence of these viruses for these hosts [29].

Results (Sundanese) 1:

Ebola di Sato: primata Non-manusa nu sacara umum kacida susceptible kana inféksi Filovirus. Wabah badag nepi ka tiwasna inféksi virus Ebola geus dilaporkeun dina populasi liar Gorila (gorila gorila) jeung simpanse (genus pan). Dina monyét rhesus (Macaca mulatta), monyet cynomolgus (Macaca fascicularis), monyet héjo Afrika (Cercopithecus aethiops) jeung baboons (spésiés Papio) inoculated jeung virus Marburg atawa virus Zaire Ebola nu Mangsa inkubasi 4-6 poé ieu dituturkeun ku hiji awal kasar panyakit klinis ditandaan ku petechiae, ecchymosis, hemorrhagic pharyngitis, hematemesis, melena jeung sujud. Inféksi ampir sok ends di pati. Nu pathogenesis inféksi filovirus nyaéta tétéla sarua dina eta primata non-manusa jeung manusa. Beurit jeung babi guinea teu kacida susceptible ka widang isolates of filoviruses tapi rodent diadaptasi galur virus teu dipicuna panyakit seragam nepi ka tiwasna jeung geus garapan pikeun nguji vaksin jeung agén terapi [15]. Lamun inoculated ékspériméntal di sagala rupa spésiés monyét, virus Ebola ngabalukarkeun kasakit parna dicirikeun di mimiti ku muriang jeung depresi dituturkeun ku diare, petechiae, languor, shock sarta pamustunganana maot [28] .In nu macaques Cynomolgus diimpor ka Italy jeung Amérika Sarikat ti Filipina, inféksi nu dibalukarkeun ku galur Reston tina panyakit virus dihasilkeun sarta laju fatality kasus luhur. Antibodi geus ogé geus kapanggih dina primata dunya heubeul séjén [21]. Nu Sudan jeung Reston subtypes virus Ebola nu saeutikna pathogenic pikeun primata jeung babi guinea, killing ngan mangrupa pecahan sato inoculated jeung un-passaged virus. Serial petikan ngaronjatkeun virulence virus ieu pikeun sarwa ieu [29].