Gammaherpesviruses inhibit MHC-II-r

Gammaherpesviruses inhibit MHC-II-restricted antigen presentation. SOCS3 expression is upregulated by KSHV infection, which inhibits IFN-γ-induced phosphorylation of STAT1, thereby downregulating the transactivation of CIITA gene. BZLF1 and vIRF3 ...

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Gammaherpesviruses ингибируют MHC-II-ограниченный презентацию антигена. SOCS3 выражение активируется инфекцией KSHV, который ингибирует ИФН-γ-индуцированную фосфорилирование STAT1, тем самым downregulating трансактивацию гена CIITA. BZLF1 и vIRF3 ...

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gammaherpesviruses препятствуют мхк II только презентация антигена.socs3 выражение upregulated в kshv инфекции, которая препятствует IFN - гамма - искусственное фосфорилирование из stat1, тем самым downregulating в transactivation из ciita джин.bzlf1 и virf3.

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