The present data show that, in comparison with conditions of moderate hyperglycemia (10.5 mmol/ 1), during euglycemia (5.0 mmol/l) patients with type 2 diabetes increased their caloric intake from a breakfast buffet by ~160 kcal. The increase in caloric intake involved all macronutrient components, i.e., proteins, carbohydrates, and fat, to a similar extent. On the one hand, this result supports the notion that blood glucose is a highly relevant signal to the regulation of food intake. On the other hand, since total energy influx (i.e., the sum of the energy ingested by food and infused by glucose) was virtually identical in the euglycemic and hyperglycemic condition, our data indicate a tight shortterm regulation of total caloric intake that may even work independently of the currently sensed blood glucose level.