As a typical n-type semiconducting metal oxide, tin oxide (SnO2 ) is the most potential metal oxide used as gas-sensing material because of its low cost and good chemical stability. Indium oxide (In2O3) has also been proven to be a highly sensing material for the detection of various gases [23]. Moreover, the adding of palla- dium and platinum has been proved to be a simple and efficient route to enhance the sensing properties because of the catalyst nanoparticles catalytically activating the dissociation of molecular oxygen, inducing a deeper layer. At the same time, they can exert an active effect as catalysts on dehydrogenation and ring-opening of hydrocarbons [11]. However, to the best of our knowledge, there are no reports on the preparation of SnO2-Pd-Pt-In2O3 compos- ite and no reports have shown that SnO2-Pd-Pt-In2O3 composite has an excellent response for methanol. In this contribution, we newly designed, the pure tin oxide (SnO2) was synthesized by a facile hydrothermal method. Then the palladium-platinum-In2 O3 composited nanocrystalline SnO2 (SnO2 -Pd-Pt-In2 O3 composite) was prepared via a solid-phase reaction method. Subsequently, the phase and microstructures of the composite were thoroughly characterized. The sensor based on SnO2-Pd-Pt-In2O3 composite exhibited good methanol sensing properties, especially for the gas response which is ultra-high. Furthermore, a possible sens- ing mechanism of the composite is discussed. It is believed that the composite could further provide potential for application as a highly effective methanol gas sensor.