The coacervating system containing

The coacervating system containing grewia gum and gelatin (2 and 8% w/v) is higher than the system in which acacia and gelatin were used (1% w/v each). This may be responsible for the high bulk density obtained for the drug in the system containing grewia gum and gelatin. So also is the tapped density. Both bulk and tapped densities affect the packing characteristics of powdered material (Aulton, 1999). Increase in tapped density is advantageous in tabletting and encapsulation because of reduced fill volume.
The particle size of materials is another property that affects the packing characteristic of the materials. The mean particle size obtained for ibuprofen microcapsules containing grewia gum and gelatin is 790 μm. The corresponding mean particle size of microcapsules made with acacia and gelatin is 1200 μm. These sizes are within the range of size of microcapsules reported elsewhere (Kumar, 2000). It could be seen that the acacia and gelatin coacervating system produced a higher particle size of the drug than that containing grewia gum and gelatin. Particle size affects flow rates, angle of repose, bulk and tapped densities and the release characteristics of granules, tablets and capsules (Aulton, 1999). The results of the particle size analysis carried out to determine the granulometric distribution and mean particle size of the microcapsules is reflected in the graphs below.
02040608010012018038058078098011801380Particle diameter (μm)Fig.1: Cumulative percent oversize versus particle size for Ibuprofen microcapsules containing grewia gum and gelatinCumulative percent oversize (%)Series1
Figure 1: Cumulative Percent Oversize vs. Particle Size for Ibuprofen Microcapsules containing Grewia Gum and Gelatin.

Results (Indonesian) 1:

The coacervating system containing grewia gum and gelatin (2 and 8% w/v) is higher than the system in which acacia and gelatin were used (1% w/v each). This may be responsible for the high bulk density obtained for the drug in the system containing grewia gum and gelatin. So also is the tapped density. Both bulk and tapped densities affect the packing characteristics of powdered material (Aulton, 1999). Increase in tapped density is advantageous in tabletting and encapsulation because of reduced fill volume.The particle size of materials is another property that affects the packing characteristic of the materials. The mean particle size obtained for ibuprofen microcapsules containing grewia gum and gelatin is 790 μm. The corresponding mean particle size of microcapsules made with acacia and gelatin is 1200 μm. These sizes are within the range of size of microcapsules reported elsewhere (Kumar, 2000). It could be seen that the acacia and gelatin coacervating system produced a higher particle size of the drug than that containing grewia gum and gelatin. Particle size affects flow rates, angle of repose, bulk and tapped densities and the release characteristics of granules, tablets and capsules (Aulton, 1999). The results of the particle size analysis carried out to determine the granulometric distribution and mean particle size of the microcapsules is reflected in the graphs below.02040608010012018038058078098011801380Particle diameter (μm)Fig.1: kumulatif kebesaran persen versus ukuran partikel untuk Ibuprofen microcapsules yang mengandung grewia gum dan gelatinCumulative persen kebesaran (%) Series1Gambar 1: Kumulatif persen kebesaran vs ukuran partikel untuk Ibuprofen Microcapsules yang mengandung Grewia karet dan Gelatin.

Results (Indonesian) 2:

Sistem coacervating mengandung gum grewia dan gelatin (2 dan 8% w / v) lebih tinggi dari sistem di mana akasia dan gelatin yang digunakan (1% b / v masing-masing). Ini mungkin bertanggung jawab untuk bulk density tinggi diperoleh untuk obat dalam sistem yang mengandung gum grewia dan gelatin. Begitu juga adalah kepadatan disadap. Kedua massal dan kepadatan mengetuk mempengaruhi karakteristik kemasan dari bahan bubuk (Aulton, 1999). Peningkatan kepadatan disadap adalah menguntungkan dalam tablet dan enkapsulasi karena mengurangi volume mengisi.
Ukuran partikel bahan adalah properti lain yang mempengaruhi karakteristik kemasan dari bahan. Mean ukuran partikel diperoleh untuk mikrokapsul ibuprofen mengandung gum grewia dan gelatin adalah 790 m. Yang sesuai ukuran partikel rata-rata mikrokapsul dibuat dengan akasia dan gelatin adalah 1200 m. Ukuran ini dalam kisaran ukuran mikrokapsul dilaporkan di tempat lain (Kumar, 2000). Hal ini dapat dilihat bahwa akasia dan gelatin coacervating sistem menghasilkan ukuran partikel yang lebih tinggi dari obat dari itu mengandung gum grewia dan gelatin. Ukuran partikel mempengaruhi laju aliran, sudut diam, curah dan kepadatan disadap dan karakteristik pelepasan butiran, tablet dan kapsul (Aulton, 1999). Hasil analisis ukuran partikel dilakukan untuk menentukan distribusi granulometri dan berarti ukuran partikel mikrokapsul tercermin dalam grafik di bawah ini.
02040608010012018038058078098011801380Particle diameter (m) Gambar 1: kumulatif persen kebesaran dibandingkan ukuran partikel untuk mikrokapsul Ibuprofen mengandung gum grewia dan gelatinCumulative persen kebesaran (%) Series1
Gambar 1: kumulatif persen Oversize vs Ukuran Partikel untuk Ibuprofen Mikrokapsul mengandung Grewia Gum dan Gelatin.