Some patients require higher rHuEPO doses to achieve an adequate response. In the critically ill, there is evidence suggesting that a frequent rHuEPO dosing interval (e.g., 150-300 U/kg/day) may be more effective than single weekly doses (e.g., 600 U/kg). If the cause of poor response to rHuEPO cannot be identified or corrected, consider using a higher dose