Diffusion predominates below the 0.1 μm diameter particle size. Impaction and interception predominate above 0.4 μm. In between, near the most penetrating particle size (MPPS) 0.3 μm, both diffusion and interception are comparatively inefficient. Because this is the weakest point in the filter's performance, the HEPA specifications use the retention of these particles to classify the filter.
Lastly, it is important to note that HEPA filters are designed to arrest very fine particles effectively, but they do not filter out gasses and odor molecules. Circumstances requiring filtration of volatile organic compounds, chemical vapors, cigarette, pet, and/or flatulence odors call for the use of an activated carbon (charcoal) filter instead of or in addition to a HEPA filter. (ZAND)