BACKGROUND—Contact lens induced pap

BACKGROUND—Contact lens induced papillary conjunctivitis (CLPC) continues to be a major
cause of dropout during contact lens extended wear. This retrospective study explores risk factors
for the development of CLPC during silicone hydrogel lens extended wear.
METHODS—Data from 205 subjects enrolled in the Longitudinal Analysis of Silicone Hydrogel
Contact Lens (LASH) study wearing lotrafilcon A silicone hydrogel lenses for up to 30 days of
continuous wear were used to determine risk factors for CLPC in this secondary analysis of the
main cohort. The main covariates of interest included substantial lens-associated bacterial
bioburden, and topographically determined lens base curve-to-cornea fitting relationships.
Additional covariates of interest included history of prior adverse events, time of year, race,
education level, gender and other subject demographics. Statistical analyses included univariate
logistic regression to assess the impact of potential risk factors on the binary CLPC outcome, and
Cox proportional hazards regression to describe the impact of those factors on time-to-CLPC
diagnosis.
RESULTS—Across 12 months of follow-up, 52 subjects (25%) experienced CLPC. No
associations were found between CLPC development and the presence of bacterial bioburden,
lens-to-cornea fitting relationships, history of prior adverse events, gender or race. CLPC
development followed the same seasonal trends as the local peaks in environmental allergans.
CONCLUSIONS—Lens fit and biodeposits, in the form of lens associated bacterial bioburden,
were not associated with the development of CLPC during extended wear with lotrafilcon A
silicone hydrogel lenses

Results (Indonesian) 2:

Lensa Kontak LATAR BELAKANG-diinduksi konjungtivitis papiler (CLPC) terus menjadi besar
penyebab putus sekolah selama lensa kontak diperpanjang memakai. Penelitian retrospektif ini mengeksplorasi faktor risiko
untuk pengembangan CLPC selama lensa silikon hidrogel diperpanjang pakai.
METODE-data dari 205 subyek yang terdaftar dalam Analisis Longitudinal Silicone Hydrogel
Lensa Kontak (Lash) studi mengenakan lotrafilcon A lensa silikon hidrogel sampai 30 hari
pakai terus menerus digunakan untuk menentukan faktor risiko CLPC dalam analisis sekunder ini dari
kelompok utama. Kovariat utama kepentingan termasuk lensa-terkait bakteri substansial
bioburden, dan basis lensa kurva-to-kornea hubungan pas topografi ditentukan.
kovariat menarik termasuk sejarah efek samping sebelumnya, waktu tahun, ras,
tingkat pendidikan, jenis kelamin dan subjek lainnya demografi. Analisis statistik termasuk univariat
regresi logistik untuk menilai dampak dari faktor-faktor risiko potensial pada hasil biner CLPC, dan
Cox bahaya proporsional regresi untuk menggambarkan dampak dari faktor-faktor tersebut di waktu-ke-CLPC
diagnosis.
HASIL-Di 12 bulan masa tindak lanjut, 52 subyek (25%) mengalami CLPC. Tidak ada
hubungan yang ditemukan antara pengembangan CLPC dan adanya beban biologis bakteri,
hubungan pas lensa-to-kornea, sejarah efek samping sebelumnya, jenis kelamin atau ras. CLPC
pengembangan mengikuti tren musiman sama dengan puncak lokal di allergans lingkungan.
KESIMPULAN-Lens fit dan biodeposits, dalam bentuk lensa terkait bioburden bakteri,
yang tidak terkait dengan perkembangan CLPC selama memakai diperpanjang dengan lotrafilcon A
lensa silicone hydrogel