The prevalence of these stages of CKD in the US population is as follows: 1.8% for stage 1, 3.2% for stage 2, 7.7% for stage 3 and 0.35 % for stages 4 and 5. Patients with stage 3 or 4 disease progress to end stage renal disease or stage 5 at a rate of 1.5% per year. Stage 1 or 2 CKD patients progress to more advanced stages at approximately 0.5% per year. In addition, the NKF KDOQI provides evidence-based, clinical practice guidelines for all stages of chronic kidney disease to optimize management of related complications. Twelve sets of guidelines have been published and are available on the NKF web site (http://www.kidney.org/professionals/KDOQI/). Each of the complications discussed in this article is addressed by the NKF KDOQI guidelines.