ummary: This gene encodes a tumor s

ummary: This gene encodes a tumor suppressor protein that acts as
an antagonist of the Wnt signaling pathway. It is also involved in
other processes including cell migration and adhesion,
transcriptional activation, and apoptosis. Defects in this gene
cause familial adenomatous polyposis (FAP), an autosomal dominant
pre-malignant disease that usually progresses to malignancy.
Disease-associated mutations tend to be clustered in a small region
designated the mutation cluster region (MCR) and result in a
truncated protein product. [provided by RefSeq, Jul 2008].

Results (Indonesian) 1:

ummary: gen ini mengkode protein supresor tumor yang bertindak sebagai antagonis Wnt jalur signaling. Itu juga terlibat dalam proses lainnya termasuk migrasi sel dan adhesi, transcriptional aktivasi dan apoptosis. Cacat gen ini menyebabkan poliposis adenomatosa familial (TPI), autosomal dominan pra-ganas penyakit yang biasanya berlangsung untuk keganasan. Mutasi-mutasi yang terkait penyakit cenderung berkumpul di wilayah kecil Ruangan Khusus mutasi cluster wilayah (MCR) dan mengakibatkan Produk protein terpotong. [disediakan oleh RefSeq, Juli 2008].