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•Combines the principle of dilution methods with that of diffusion methods in order to determine the MIC value•Based on the possibility of creating a concentration gradient of the antimicrobial agent tested in the agar medium•The Etest® (BioMerieux) is a commercial version of this techniqueepsilometer•A strip impregnated with an increasing concentration gradient of the antimicrobial agent from one end to the other is deposited on the agar surface, previously inoculated with the microorganisms testedAntimicrobial gradient method (Etest)
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