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for erythromycin illustrates its channel hydrate nature, where
almost all of the water is sorbed below 10% RH.
The partial molar enthalpy and entropy of sorbed water (relative
to bulk liquid water at its saturation pressure) for each
of the solids are presented in Figure 3. Notice that of the crystalline
solids—genistein, griseofulvin, indomethacin, and lactose
monohydrate—genistein, indomethacin, and lactosemonohydrate
generally display endothermic water enthalpy relative
to bulk water. Griseofulvin is distinctive in its slightly exothermicwater
enthalpy. The channel hydrate erythromycin exhibits
highly exothermic water enthalpy up until the channels are
filled, and the amorphous polymer PVP also exhibits significant
exothermic water enthalpy compared to bulk water.
Given that lactose is a monohydrate with potential to dehydrate
partially on the surface in the drying process, it was
subjected to drying at 25◦C in addition to the 40◦C result presented
in Figure 3. The partial molar enthalpy profiles of lactose
dried at the two conditions are presented in Figure 4. Although
the average 25◦C drying curve is slightly more endothermic at
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