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Other agents may be effective but are not FDA-approved for alcohol dependence. Short-term randomized trials have shown improved rates of abstinence and reduced heavy drinking with topiramate (but with side effects including weightloss, dizziness, and neurocognitive problems, often leading to discontinuation), reductions in recurrent drinking with selective serotonin-reuptake inhibitors in persons with later-onset alcohol dependence or concurrent depression, and reduced consumption with baclofen or ondansetron, the latter in persons with early-onset alcohol dependence. However, data from longer-term studies are needed to establish the effectiveness of these agents in patients with alcohol dependence.
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