Statistical analysis
Statistical analyses of the data accumulated throughout
October 2011 were performed. Overall survival (OS) wasdefined as the time between diagnosis and the end of
the trial or death, and disease-free survival (DFS) was
defined as the time from CR to relapse or death while
still in CR. Survival curves were estimated using the
Kaplan–Meier method, and the statistical significance of
differences in survival was determined using the logrank
test.
The influence of prognostic factors including age,
white blood cell (WBC) count, and MRD status on DFS
was estimated with multivariate Cox regression analysis.
The level of statistical significance was set at 0.05.